Temperature Effect on IgE Binding to CD23 Versus Fc RI
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Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc«RI): role in asthma
Polymorphonuclear neutrophils (PMNs) are important effector cells in host defense and the inflammatory response to antigen. The involvement of PMNs in inflammation is mediated mainly by the Fc receptor family, including IgE receptors. Recently, PMNs were shown to express two IgE receptors (CD23/Fc«RII and galectin-3). In allergic diseases, the dominant role of IgE has been mainly ascribed to it...
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Immunoglobulin (Ig) E antibodies mediate allergic responses by binding to specific high affinity receptors, Fc epsilon RI, on mast cells and basophils. Previous studies have shown that the principal Fc epsilon RI binding site is located on the third constant domain, Fc epsilon 3, of IgE. Based on a model of the IgE Fc epsilon 3 (which is homologous to the second constant domain of IgG), homolog...
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تاریخ انتشار 2003